Autor(es):
Mazya, M ; Ahmed, N ; Ford, G ; Hobohm, C ; Mikulik, R ; Paiva Nunes, A ; Wahlgren, N
Data: 2014
Identificador Persistente: http://hdl.handle.net/10400.17/3874
Origem: Repositório do Centro Hospitalar de Lisboa Central, EPE
Assunto(s): HSJ NEU; Age Factors; Aged; Brain Ischemia* / chemically induced; Brain Ischemia* / diagnostic imaging; Brain Ischemia* / mortality; Cerebral Hemorrhage* / chemically induced; Female; Male; Cerebral Hemorrhage* / diagnostic imaging; Humans; Cerebral Hemorrhage* / mortality; Fibrinolytic Agents / adverse effects*; Fibrinolytic Agents / therapeutic use; Middle Aged; Radiography; Recombinant Proteins / adverse effects; Recombinant Proteins / therapeutic use; Retrospective Studies; Stroke* / diagnostic imaging; Stroke* / drug therapy; Thrombolytic Therapy / adverse effects*; Tissue Plasminogen Activator / adverse effects*; Tissue Plasminogen Activator / therapeutic use
Descrição
Background and purpose: Intracerebral hemorrhage after treatment with intravenous recombinant tissue-type plasminogen activator for ischemic stroke can occur in local relation to the infarct, as well as in brain areas remote from infarcted tissue. We aimed to describe risk factors, 3-month mortality, and functional outcome in patients with the poorly understood complication of remote intracerebral hemorrhage, as well as local intracerebral hemorrhage. Methods: In this study, 43 494 patients treated with intravenous recombinant tissue-type plasminogen activator, with complete imaging data, were enrolled in the Safe Implementation of Treatments in Stroke-International Stroke Thrombolysis Register (SITS-ISTR) during 2002 to 2011. Baseline data were compared among 970 patients (2.2%) with remote parenchymal hemorrhage (PHr), 2325 (5.3%) with PH, 438 (1.0%) with both PH and PHr, and 39 761 (91.4%) without PH or PHr. Independent risk factors for all hemorrhage types were obtained by multivariate logistic regression. Results: Previous stroke (P=0.023) and higher age (P<0.001) were independently associated with PHr, but not with PH. Atrial fibrillation, computed tomographic hyperdense cerebral artery sign, and elevated blood glucose were associated with PH, but not with PHr. Female sex had a stronger association with PHr than with PH. Functional independence at 3 months was more common in PHr than in PH (34% versus 24%; P<0.001), whereas 3-month mortality was lower (34% versus 39%; P<0.001). Conclusions: Differences between risk factor profiles indicate an influence of previous vascular pathology in PHr and acute large-vessel occlusion in PH. Additional research is needed on the effect of pre-existing cerebrovascular disease on complications of recanalization therapy in acute ischemic stroke.
