Author(s): Branco Caetano, F ; Milheiro Silva, T ; Gonçalves, C ; Dias, AI ; Brito, MJ
Date: 2022
Persistent ID: http://hdl.handle.net/10400.17/4510
Origin: Repositório do Centro Hospitalar de Lisboa Central, EPE
Subject(s): Diet, Ketogenic; Tuberculosis; Chemical and Drug Induced Liver Injury; HDE INF PED; HDE NEU PED; HDE GAS PED
When therapy with hepatotoxic drugs is being considered, all other possible contributing agents of liver damage should be held to account. While not generally considered a risk factor, we present 2 cases in which ketogenic diet (KD) may have played a role in liver injury due to antituberculosis drugs. Ketogenic diet has been linked to liver injury, and while its pathophysiology remains obscure, carnitine depletion could play a role, as it is a mechanism of liver damage common to KD and antituberculosis drug regimens.
