STATs in Lung Development: Distinct Early and Late Expression, Growth Modulation and Signaling Dysregulation in Congenital Diaphragmatic Hernia

• Author(s): Piairo, P ; Moura, RS ; Baptista, MJ ; Correia-Pinto, J ; Nogueira-Silva, C
• Date: 2018
• Persistent ID: http://hdl.handle.net/10400.23/1244
• Origin: Repositório Científico do Hospital de Braga
• Subject(s): Hérnias Diafragmáticas Congénitas; Pulmão
• Document Type: Journal article
• Language: English
• Contributor(s): Repositório Científico do Hospital de Braga

Description

Congenital diaphragmatic hernia (CDH) is a life-threatening developmental anomaly, intrinsically combining severe pulmonary hypoplasia and hypertension. During development, signal transducers and activators of transcription (STAT) are utilized to elicit cell growth, differentiation, and survival.