STATs in Lung Development: Distinct Early and Late Expression, Growth Modulation and Signaling Dysregulation in Congenital Diaphragmatic Hernia

• Autor(es): Piairo, P ; Moura, RS ; Baptista, MJ ; Correia-Pinto, J ; Nogueira-Silva, C
• Data: 2018
• Identificador Persistente: http://hdl.handle.net/10400.23/1244
• Origem: Repositório Científico do Hospital de Braga
• Assunto(s): Hérnias Diafragmáticas Congénitas; Pulmão
• Tipo de Documento: Artigo científico
• Idioma: Inglês
• Contribuidor(es): Repositório Científico do Hospital de Braga

Descrição

Congenital diaphragmatic hernia (CDH) is a life-threatening developmental anomaly, intrinsically combining severe pulmonary hypoplasia and hypertension. During development, signal transducers and activators of transcription (STAT) are utilized to elicit cell growth, differentiation, and survival.