Accuracy of the new rapid test for monitoring adalimumab levels

• Autor(es): Rocha, C ; Afonso, J ; Lago, P ; Arroja, B ; Vieira, AI ; Dias, CC ; Magro, F
• Data: 2019
• Identificador Persistente: http://hdl.handle.net/10400.23/1323
• Origem: Repositório Científico do Hospital de Braga
• Assunto(s): Adalimumab
• Tipo de Documento: Artigo científico
• Idioma: Inglês
• Contribuidor(es): Repositório Científico do Hospital de Braga

Descrição

The loss of response to adalimumab (ADL) has been related to low serum concentrations at trough. Currently, most methods commercially available for the quantification of ADL are enzyme-linked immunosorbent assay (ELISA) based, with a turnaround time of approximately 8 h, delaying the target dosage adjustment to the subsequent infusion. In this study, we aimed to evaluate the performance of the newly available rapid-test ADL quantification assay by comparing it with three established ELISA methods, using spiked samples and a set of clinical samples.