Genetic variants of CYP2C9 and IL-6 on female infertility

• Author(s): Cardoso, R. ; Gonçalves, A. ; da Silva, J.M. ; Oliveira, C. ; Xavier, P. ; Alves, H. ; Barros, A. ; Botelho, M.C.
• Date: 2017
• Persistent ID: http://hdl.handle.net/10400.18/4800
• Origin: Repositório Científico do Instituto Nacional de Saúde
• Subject(s): Genetic Variants; Female Infertility
• Document Type: Conference object
• Language: English
• Contributor(s): Repositório Científico do Instituto Nacional de Saúde

Description

AIM: To study the polymorphic variants in CYP2C9*2*3 and the C-174G promoter polymorphism of the IL-6 gene on Infertile Women.BACKGROUND: - Infertility affects 15–20% of couples worldwide. Within the past decades, there has been a steady rise in the treatment of female infertility with several drugs; - The cytochrome P450 (CYP) genes are oxygenases involved in estrogen biosynthesis and metabolism, generation of DNA damaging procarcinogens, and response to anti-estrogen therapies used in female infertility treatments: - Interleukin-6 (IL-6) is a pleiotropic proinflammatory cytokine, highly expressed in the female urogenital tract and reproductive organs. It has been implicated in estrogen metabolism imbalance.