Author(s): Melo, Aryse Martins ; Poester, Vanice Rodrigues ; Munhoz, Lívia ; Trápaga, Mariana ; Roca, Beatriz ; Klafke, Gabriel Baracy ; Sabino, Raquel ; Stevens, David A. ; Xavier, Melissa Orzechowski
Date: 2020
Persistent ID: http://hdl.handle.net/10400.18/7703
Origin: Repositório Científico do Instituto Nacional de Saúde
Subject(s): Diphenyl Diselenide; Antifungal Susceptibility; Aspergillus; Infecções Sistémicas e Zoonoses
Organoselenium compounds have been showing promising antimicrobial activity against bacteria and some fungal species. Among these compounds, diphenyl diselenide (PhSe)2 is a simple and chemically stable molecule with proven low toxicity to animal hosts. Although the mechanisms of action of this molecule are not totally clear, it has been reported that it has a prooxidative activity for microorganisms, due to glutathione depletion. Given the emergence of azole resistance Aspergillus sp. isolates is a global and rising concern, research towards new molecules with antifungal potential are necessary. Thus, the aim of this study was to evaluate the in vitro susceptibility of Aspergillus spp. clinical isolates to (PhSe)2.
