Author(s):
Rodrigues Trápaga, Mariana ; Rodrigues Poester, Vanice ; Sanchotene, Karine Ortiz ; Martins Melo, Aryse ; Benelli, Jéssica Louise ; Basso, Rossana Patricia ; Klafke, Gabriel Baracy ; Fernandes Ramos, Daniela ; Veríssimo, Cristina ; Sabino, Raquel ; Stevens, David A. ; Xavier, Melissa Orzechowski
Date: 2022
Persistent ID: http://hdl.handle.net/10400.18/8513
Origin: Repositório Científico do Instituto Nacional de Saúde
Subject(s): Aspergillosis; Aspergillus IgG; Fungal Disease; Immunodifusion; ELISA; Infecções Sistémicas e Zoonoses
Description
Aspergillosis is a mycosis, most commonly afecting the airways. This mycosis can worsen the clinical condition of patients with concurrent lung diseases. We assayed for the presence of serum anti-A. fumigatus IgG in bronchiectasis patients from a tertiary hospital in south Brazil and evaluated the relationship with clinical outcome. Thirty-one patients with bronchiec tasis, without cystic fbrosis, were included. Clinical and epidemiological data were collected from all participants. Positive serological tests were detected in 13% (4/31) of the patients. The mortality rate for the year following the assay was, in the seropositive group, 75% (3/4), whereas in the seronegative group, 15% (4/27). An illustrative case is also shown and discussed. Our study highlights the diagnostic challenge and the possible impact of Aspergillus infection on these patients, indicating the necessity of more and larger investigations in the feld
