TNBS-induced colitis in rodents: preliminary results of a chronic model

• Author(s): Silva, Inês ; Solas, João ; Sousa, Mariana ; Modesto, Rita ; Mateus, Vanessa ; Pinto, Rui
• Date: 2019
• Persistent ID: http://hdl.handle.net/10400.21/12229
• Origin: Repositório Científico do Instituto Politécnico de Lisboa
• Subject(s): Inflammatory bowel disease; Ulcerative colitis; Crohn disease; Animal model; IDI&CA_COLITIS/2019
• Document Type: Conference object
• Language: English
• Contributor(s): RCIPL

Description

Chronic inflammatory disease of the gastrointestinal (GI) tract characterized by recurrent ulceration. Treatment of inflammatory bowel disease induce and maintain the patient in remission However do not modify or reverse the underlying pathogenic mechanism. Nonclinical studies for emerging therapeutic strategies. Aim of the study: Evaluate the efficacy of new drugs in inflammatory bowel disease through an animal model of TNBS-induced chronic colitis.