Autor(es): Garcia-Gonzalo, Francesc R. ; Soares, Helena ; Lopes, Susana S. ; Inoue, Takanari
Data: 2021
Identificador Persistente: http://hdl.handle.net/10400.21/13997
Origem: Repositório Científico do Instituto Politécnico de Lisboa
Assunto(s): Primary cilia; Ciliopathies; Ciliogenesis; Motile/immotile cilia; Cilia signaling; FCT_UIDB/00100/2020; FCT_UIDP/00100/2020
Cilia are fascinating microtubule-based compartments that project from the cell surface. Cilia can be functionally classified as motile (generating cell movement or fluid flow) or immotile (primary cilia, which transduce mechanical, optical, or chemical signals through a variety of pathways, such as Hedgehog, GPCR, Notch, Wnt, Hippo, mTOR, PDGFR, or TGFβ. Structurally, cilia are composed of a microtubule shaft (axoneme) that elongates from a membrane-anchored centriole (basal body) and are covered by a highly specialized ciliary membrane. Most human cell types form cilia, dysfunction of which leads to diseases such as cancer and ciliopathies, a diverse group of disorders affecting eyes, kidneys, and brain, among other organs. This Research Topic spans multiple aspects of motile and primary cilia composition and function, ciliary mechanisms, and the physiopathological roles of cilia in different tissues. Here we describe some of the highlights.
