Author(s):
Dias, Marta ; Rodriguez, Margarida ; Vasques, C. ; Riesenberger, Bruna ; Marques, Liliana ; Gomes, Bianca ; Pena, Pedro ; Cervantes, Renata ; Viegas, Susana ; Viegas, Carla
Date: 2024
Persistent ID: http://hdl.handle.net/10400.21/17652
Origin: Repositório Científico do Instituto Politécnico de Lisboa
Subject(s): Occupational health; Occupational exposure; Aspergillus fumigatus; Mutation detection; Protocol; FCT/MCTES/FSE/UE, 2023.01366.BD; UI/BD/153746/2022; CE3C unit UIDB/00329/2020; UI/BD/151431/2021; IPL/2022/InChildhealth/BI/12M; IPL/IDI&CA2023/FoodAIIEU_ESTeSL; IPL/IDI&CA2023/ASPRisk_ESTeSL; IPL/IDI&CA2023/ARAFSawmills_ESTeSL; FCT_UIDP/05608/2020; FCT_UIDB/05608/2020
Description
Aspergillus section Fumigati is one of the most common sections, in the environment. It has been found in different occupational environments, such as sawmills and waste sorting. Its cryptic species show intrinsic resistance to several antifungals. Resistance in A. fumigatus is emerging due to selective pressure caused by the prolonged use of azoles. It is often associated with mutations in the Cyp51A gene. The fungal priority pathogens list (WHO), includes A. fumigatus with critical priority. Further analysis to identify potential resistance mechanisms and mutations is needed. Objective: This evaluation aims to offer a protocol for mutation detection in Aspergillus section Fumigati isolates. It will contribute to the development of guidance that can support future occupational exposure assessments.
