Autor(es):
Gadelha, Sandra Rocha ; Alcântara, Luiz Carlos Júnior ; Costa, Gisele Calazans ; Acosta, Angelina Xavier ; Rios, Domingos ; Kashima, Simone ; Covas, Dimas Tadeu ; Castro, Bernardo Galvão ; Gadelha, Sandra Rocha ; Alcântara, Luiz Carlos Júnior ; Costa, Gisele Calazans ; Acosta, Angelina Xavier ; Rios, Domingos ; Kashima, Simone ; Covas, Dimas Tadeu ; Castro, Bernardo Galvão
Data: 2013
Origem: Oasisbr
Assunto(s): HTLV-1; Interleukin-6; Interleukin-10; Polymorphisms; Brazilian populations
Descrição
Texto completo: acesso restrito. p. 2141-2146
Submitted by Suelen Reis (suziy.ellen@gmail.com) on 2013-11-19T14:27:32Z No. of bitstreams: 1 10.1002-jmv.21341.pdf: 87640 bytes, checksum: f65e1390029fb8f906878ac4509e4c9f (MD5)
Approved for entry into archive by Rodrigo Meirelles (rodrigomei@ufba.br) on 2013-11-22T11:59:51Z (GMT) No. of bitstreams: 1 10.1002-jmv.21341.pdf: 87640 bytes, checksum: f65e1390029fb8f906878ac4509e4c9f (MD5)
Made available in DSpace on 2013-11-22T11:59:51Z (GMT). No. of bitstreams: 1 10.1002-jmv.21341.pdf: 87640 bytes, checksum: f65e1390029fb8f906878ac4509e4c9f (MD5) Previous issue date: 2008
HTLV-1 is the etiologic agent of ATL and HAM/TSP. The majority of HTLV-1-infected individuals remain asymptomatic, indicating that the infection alone is not sufficient to cause the diseases. It has been reported that cytokine gene polymorphisms, including polymorphisms at IL-6 and IL-10 gene, might be important. We analyzed SNP in the promoter region of the IL-6: −174, −572, −597, and −634 positions, and IL-10: −592 position to evaluate the role of these polymorphisms in the HAM/TSP pathogenesis in 133 HTLV-1 infected individuals and in 100 healthy individuals from Salvador, Bahia, Brazil. The −634C allele frequencies were higher among HAM/TSP patients (21.2%) than among oligosymptomatic (6.5%; P = 0.038) and asymptomatic (9.5%; P = 0.025) subjects. Similarly, the −174G allele frequencies were higher in HAM/TSP patients than in oligosymptomatic patients (P = 0.02). Moreover, the −634GC/−174GG genotype combination was identified at a higher frequency (38.5%) in the HAM/TSP patients than in subjects with other clinical status (8.7%; P = 0.016 for oligosymptomatic and 15.5%, P = 0.012 for asymptomatic patients). However, the multivariate logistic regression including the genotypes of the three studied loci showed that only −634 C IL-6 carriers remain as significant and independent TSP/HAM predictor (odds ratio [OR] = 5.31; 95% [CI] = 1.60–17.56; P = 0.006). We suggest that −634 G C in IL-6 could contribute to HAM/TSP development and that identification of the collective influence of several cytokine polymorphisms, their prevalence, and their interaction could help to better understand this disease.
