Author(s): Siqueira, João Máximo de ; Bomm, Mauro Dionei ; Pereira, Núbia Fernanda Gomes ; Garcez, Walmir Silva ; Boaventura, Maria Amélia Diamantino
Date: 2012
Origin: Oasisbr
Subject(s): Alcaloides; Annonaceae; Agentes Biológicos - isolamento & purificação; Plantas; Alkaloids; Biological Agents - isolation & purification; Plants
Activity - guided isolation of constituents of Unonopsis lindmanii - Annonaceae, based on the brine shrimp lethality bioassay. Extracts obtained from leaves, seeds and bark of Unonopsis lindmanii were evaluated by means of Brine Shrimp Lethality test (BSL). Through bioassay-guided chromatographic fractionation, liriodenine, an oxoaporphine alkaloid, was isolated from the bark extracts as the bioactive compound. Two additional inactive known alkaloids, unonopsine and lysicamine were also isolated from the bark extracts.
