Autor(es): Santos, Francisco ; Moreira, Cristiana ; Nobrega-Pereira, Sandrina ; Jesus, Bruno Bernardes De
Data: 2019
Identificador Persistente: http://hdl.handle.net/10451/54184
Origem: Repositório da Universidade de Lisboa
Assunto(s): EMT; Aging; Cellular reprogramming; Epithelial–mesenchymal transition; Fibrosis
Epithelial⁻mesenchymal transition (EMT) is a cellular process by which differentiated epithelial cells undergo a phenotypic conversion to a mesenchymal nature. The EMT has been increasingly recognized as an essential process for tissue fibrogenesis during disease and normal aging. Higher levels of EMT proteins in aged tissues support the involvement of EMT as a possible cause and/or consequence of the aging process. Here, we will highlight the existing understanding of EMT supporting the phenotypical alterations that occur during normal aging or pathogenesis, covering the impact of EMT deregulation in tissue homeostasis and stem cell function.
