Author(s): Santos, Francisco ; Moreira, Cristiana ; Nobrega-Pereira, Sandrina ; Jesus, Bruno Bernardes De
Date: 2019
Persistent ID: http://hdl.handle.net/10451/54184
Origin: Repositório da Universidade de Lisboa
Subject(s): EMT; Aging; Cellular reprogramming; Epithelial–mesenchymal transition; Fibrosis
Epithelial⁻mesenchymal transition (EMT) is a cellular process by which differentiated epithelial cells undergo a phenotypic conversion to a mesenchymal nature. The EMT has been increasingly recognized as an essential process for tissue fibrogenesis during disease and normal aging. Higher levels of EMT proteins in aged tissues support the involvement of EMT as a possible cause and/or consequence of the aging process. Here, we will highlight the existing understanding of EMT supporting the phenotypical alterations that occur during normal aging or pathogenesis, covering the impact of EMT deregulation in tissue homeostasis and stem cell function.
