Autor(es): Cappi, Carolina ; Hounie, Ana Gabriela ; Mariani, Daniel B. ; Diniz, Juliana Belo ; Silva, Aderbal R. T. ; Reis, Viviane N. S. ; Busso, Ariane F. ; Silva, Amanda Goncalves ; Fidalgo, Felipe ; Rogatto, Silvia Regina [UNESP] ; Miguel, Euripedes C. ; Krepischi, Ana C. ; Brentani, Helena
Data: 2015
Identificador Persistente: http://hdl.handle.net/11449/117413
Origem: Oasisbr
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Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Copy number variations (CNVs) have been previously associated with several different neurodevelopmen al psychiatric disorders, such as autism, schizophrenia, and attention deficit hyperactivity disorder (ADHD). The present study consisted of pilot genorne-wide screen for CNVs in a cohort of 16 patients with early-onset obsessive-compulsive disorder (OCD) and 2 mentally healthy individuals, using array-based comparative enomic hybridization (aCGH) on 44K arrays. A small rare nal inherited microdeletion (-64 kb) was identified in chromosome 15q13.3 of one male patient with very early onset have OCD. The deletion encompassed part of the FA/IN1 gene, which is involved with the glutamatergic system This finding supports the hypothesis of a complex network of several genes expressed in the brain cant ibuting for h genetic risk of OCD, and also supports the glutamatergic involvement in OCD, which has been previsously reported in the literature.
Univ Sao Paulo, Sch Med, Inst & Dept Psychiat, Sao Paulo, Brazil
Univ Sao Paulo, Inst Math & Stat, Inter Inst Grad Program Bioinformat, Sao Paulo, Brazil
AC Camargo Canc Ctr, Int Res Ctr, Sao Paulo, Brazil
Sao Paulo State Univ, Sch Med, Sao Paulo, Brazil
Univ Fed Sao Paulo, UPIA, Sao Paulo, Brazil
Sao Paulo State Univ, Sch Med, Sao Paulo, Brazil
FAPESP: 08/11537-7
CNPq: MCT/CNPq 14/2008
