Autor(es): Cunha, Marcelo Rodrigues da ; Menezes, Fernanda Araujo ; Santos, Geovane Ribeiro dos ; Lopes Pinto, Clovis Antonio ; Barraviera, Benedito [UNESP] ; Amaro Martins, Virginia da Conceicao ; Guzzi Plepis, Ana Maria de ; Ferreira Junior, Rui Seabra [UNESP]
Data: 2015
Identificador Persistente: http://hdl.handle.net/11449/129396
Origem: Oasisbr
Assunto(s): Bioceramic; Fibrin sealant; Bone regeneration
Made available in DSpace on 2015-10-21T21:00:26Z (GMT). No. of bitstreams: 0 Previous issue date: 2015-01-01. Added 1 bitstream(s) on 2015-10-22T09:52:40Z : No. of bitstreams: 1 S1516-14392015000100196.pdf: 3616498 bytes, checksum: 33960cf31a6f3e740ed95b36723957c8 (MD5)
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Biomaterials are used as a promising alternative to bone grafts, including bioceramics whose composition resembles that of bone and fibrin sealants due to their hemostatic properties. The objective was to evaluate the repair of cranial defects in 40 rats, grafted with hydroxyapatite and a new fibrin sealant derived from snake venom. The animals were divided into four groups: C (control, no graft); Ha (hydroxyapatite); FS (fibrin sealant), and HaFS (hydroxyapatite and fibrin sealant). The animals were euthanized 2 and 6 weeks after surgery and wound area were submitted to analysis. After 2 weeks, immature bone was formed from the borders of the defect and in groups Ha and HaFS, few hydroxyapatite particles were surrounded by new bone. After 6 weeks, the new bone was mature and surrounded several hydroxyapatite particles, without connective tissue interposition and the volume of new bone was higher in HaFS group. The hydroxyapatite in combination with the new fibrin sealant accelerates bone repair.
Ctr Univ Padre Anchieta UniAnchieta, Lab Anat, BR-13207270 Jundiai, SP, Brazil
Fac Med Jundiai FMJ, Dept Morfol &Patol Basica, BR-13202550 Jundiai, SP, Brazil
Univ Estadual Paulista Julio de Mesquista Filho U, CEVAP, BR-18610307 Botucatu, SP, Brazil
Univ Sao Paulo, Inst Quim Sao Carlos, BR-13566590 Sao Carlos, SP, Brazil
Univ Estadual Paulista Julio de Mesquista Filho, Departamento de Doenças Tropicais e Diagnóstico Por Imagem, Centro de Estudos de Venenos e Animais Peçonhentos (CEVAP), BR-18610307 Botucatu, SP, Brazil
FAPESP: 2012/02689-3
FAPESP: 2009/53846-9
FAPESP: 2009/06280-0
FAPESP: 2012/08101-8
CNPq: 563582/2010-3
CAPES: 1219/2011
CAPES: 23038.000823/2011-21
