Descrição
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Brazilian Society of Tropical Medicine and Hygiene
Brazilian Society of Infectology and Sociedade Paulista de Infectologia
Departamento de Molestias Infecciosas e Parasitarias da FMUSP
Paracoccidioidomycosis is a systemic fungal disease occurring in Latin America that is associated with rural environments and agricultural activities. However, the incidence and prevalence of paracoccidiodomycosis is underestimated because of the lack of compulsory notification. If paracoccidiodomycosis is not diagnosed and treated early and adequately, the endemic fungal infection could result in serious sequelae. While the Paracoccidioides brasiliensis (P. brasiliensis) complex has been known to be the causal agent of paracoccidiodomycosis, a new species, Paracoccidioides lutzii (P. lutzii), has been reported in Rondonia, where the disease has reached epidemic levels, and in the Central West and Para. Accurate diagnoses and availability of antigens that are reactive with the patients' sera remain significant challenges. Therefore, the present guidelines aims to update the first Brazilian consensus on paracoccidioidomycosis by providing evidence-based recommendations for bedside patient management. This consensus summarizes etiological, ecoepidemiological, molecular epidemiological, and immunopathological data, with emphasis on clinical, microbiological, and serological diagnosis and management of clinical forms and sequelae, as well as in patients with comorbidities and immunosuppression. The consensus also includes discussion of outpatient treatments, severe disease forms, disease prevalence among special populations and resource-poor settings, a brief review of prevention and control measures, current challenges and recommendations.
Univ Sao Paulo, Fac Med, Dept Molestias Infecciosas & Parasitarias, Sao Paulo, SP, Brazil
Univ Estadual Paulista, Fac Med Botucatu, Dept Doencas Tropicais & Diagnost Imagem, Botucatu, SP, Brazil
Univ Fed Sao Paulo, Escola Paulista Med, Dept Med, Sao Paulo, SP, Brazil
Univ Fed Parana, Dept Saude Comunitaria, Curitiba, Parana, Brazil
Univ Sao Paulo, Fac Med, Hosp Clin, Div Molestias Infecciosas, Sao Paulo, SP, Brazil
Univ Fed Mato Grosso do Sul, Fac Med, Campo Grande, MS, Brazil
Univ Sao Paulo, Hosp Clin, Div Pneumol, Fac Med, Sao Paulo, SP, Brazil
Fundacao Oswaldo Cruz, Inst Pesquisa Clin Evandro Chagas, Rio De Janeiro, RJ, Brazil
Univ Estadual Paulista, Inst Biociencias, Dept Microbiol & Imunol, Botucatu, SP, Brazil
Univ Sao Paulo, Dept Dermatol, Fac Med, Sao Paulo, SP, Brazil
Univ Fed Uberlandia, Fac Med, Serv Infectol, Uberlandia, MG, Brazil
No Arizona Univ, Translat Genom Res Inst, Flagstaff, AZ 86011 USA
Univ Fed Triangulo Mineiro, Dept Clin Med, Fac Med, Uberaba, MG, Brazil
Univ Estadual Campinas, Dept Pediat, Fac Ciencias Med, Campinas, SP, Brazil
Univ Fed Mato Grosso, Fac Ciencias Med, Nucleo Doencas Infecciosas & Tropicais, Cuiaba, MT, Brazil
Ctr Med Trop Rondonia, Porto Velho, RO, Brazil
Secretaria Estado Saude Sao Paulo, Inst Infectol Emilio Ribas, Sao Paulo, SP, Brazil
Univ Fed Sao Paulo, Dept Microbiol & Imunol, Sao Paulo, SP, Brazil
Univ Estadual Campinas, Dept Clin Med, Fac Ciencias Med, Campinas, SP, Brazil
Univ Sao Paulo, Fac Med Ribeirao Preto, Dept Clin Med, Ribeirao Preto, SP, Brazil
Univ Estadual Paulista, Fac Med Botucatu, Dept Doencas Tropicais & Diagnost Imagem, Botucatu, SP, Brazil
Univ Estadual Paulista, Inst Biociencias, Dept Microbiol & Imunol, Botucatu, SP, Brazil
