Autor(es):
Chiari-Andreo, Bruna Galdorfini [UNESP] ; Trovatti, Eliane ; Marto, Joana ; Jose de Almeida-Cincotto, Maria Gabriela [UNESP] ; Melero, Ana ; Correa, Marcos Antonio [UNESP] ; Chiavacci, Leila Aparecida [UNESP] ; Ribeiro, Helena ; Garrigues, Teresa ; Borges Isaac, Vera Lucia [UNESP]
Data: 2018
Identificador Persistente: http://hdl.handle.net/11449/165646
Origem: Oasisbr
Assunto(s): P.guajava L./phytochemistry; P.guajava L./use in cosmetics; P.guajava L./antioxidant/chemical composition; P.guajava L/chemical stability; High Performance Liquid Chromatography
Descrição
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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
PADC-FCF-UNESP
Fundação para o Desenvolvimento da UNESP (FUNDUNESP)
Guava (Psidium guajava L.) is a native fruit of the American tropics with commercial applications for its taste, flavor and aroma. Numerous pharmacological uses have been described for it, such as the antiseptic effect of its leaves, the use of the fresh fruit and tea from its leaves for the treatment of diarrhea, dysentery, diabetes mellitus, and others. However, considering its rich composition, the guava also is a potential source of antioxidants to be used in the development of new formulations for cosmetic and/or dermatological applications, the main focus of this research. Herein, we describe the study of the phytochemical composition and the antioxidant activity of a guava extract prepared with non-toxic solvents aiming its use at biological applications. High performance liquid chromatography and mass spectrometry were employed to identify the major components, while thermoanalytical measurements and hot stage microscopy were used to assess the chemical stability of guava fruit extract. The antioxidant activity was also evaluated assessing the SOD-like activity and ABTS free radical scavenger. The results show that the extract is a rich source of phenolic compounds, such as quercetin, kaempferol, schottenol, among many others. All of the components found in guava extract exhibit biological effects according to the literature data, mainly antioxidant properties.
Univ Estadual Paulista, Fac Pharmaceut Sci, Araraquara, SP, Brazil
Univ Sao Paulo, Sao Carlos Inst Chem, Sao Carlos, SP, Brazil
Univ Sao Paulo, Sao Carlos Sch Engn, Sao Carlos, SP, Brazil
Univ Lisbon, Nanomed & Drug Delivery Syst Grp iMed UL, Fac Pharm, Lisbon, Portugal
Univ Valencia, Fac Pharm, Dept Pharm & Pharmaceut Technol, Valencia, Spain
Univ Estadual Paulista, Fac Pharmaceut Sci, Araraquara, SP, Brazil
