Author(s): Dametto, Alessandra C. [UNESP] ; Agustoni, Daniele [UNESP] ; Moreira, Thais F. [UNESP] ; Plaza, Carenina V. [UNESP] ; Prieto, Aline M. [UNESP] ; Silva, Tarsia G.A. [UNESP] ; Souza, Felipe O. [UNESP] ; Boralle, Nivaldo [UNESP] ; Maria Sorbo, Juliana [UNESP] ; Silva, Dulce H.S. [UNESP] ; Soares, Christiane P. [UNESP]
Date: 2018
Persistent ID: http://hdl.handle.net/11449/174959
Origin: Oasisbr
Subject(s): Anthocyanins; Antigenotoxicity; Chemoprevention; Eugenia jambolana; Flavonoids
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Eugenia jambolana has been used as an antioxidant, anti-inflammatory and antidiabetic. This study performed a chemical and chemopreventive screening of extracts and fractions from leaves and fruits from Eugenia jambolana. The purification of the crude extract from leaves afforded two known flavonoids, tricetin-4′-O-α-L-rhamnopyranoside (1), and myricitrin (2), whereas the purification of crude extract from fruits afforded one anthocyanin, malvidin-3-O-gentibioside (3). Additionally, seven anthocyanins were tentatively identified. The antigenotoxicity results showed that post-treatment with extracts and fractions mitigated the damage induced by hydrogen peroxide. In assessing the antimutagenicity, the samples were able to reduce the frequency of micronucleus formation for both pre-treatment and post-treatment. Also, extracts and fractions promoted the induction of quinone reductase activity. Such extracts and fractions were able to induce detoxifying enzymes and reverse DNA damage, an essential balance for its applicability as a chemopreventive agent.
NuBBE-Nucleus of Bioassays Biosynthesis and Ecophysiology of Natural Products Department of Organic Chemistry Institute of Chemistry São Paulo State University - UNESP, Rua Prof. Francisco Degni 55
Cytology and Cellular Biology Laboratory Department of Clinical Analyses School of Pharmaceutical Sciences Sao Paulo State University - UNESP Rodovia Araraquara Jaú, Km 01 - s/n, Campus Ville
Biochemistry Laboratory Department of Clinical Analyses School of Pharmaceutical Sciences Sao Paulo State University - UNESP, Rodovia Araraquara Jaú, Km 01 - s/n, Campus Ville
Cytology and Cellular Biology Laboratory Department of Clinical Analyses School of Pharmaceutical Sciences Sao Paulo State University - UNESP, 1621 Expedicionários do Brasil street, Centro
NuBBE-Nucleus of Bioassays Biosynthesis and Ecophysiology of Natural Products Department of Organic Chemistry Institute of Chemistry São Paulo State University - UNESP, Rua Prof. Francisco Degni 55
Cytology and Cellular Biology Laboratory Department of Clinical Analyses School of Pharmaceutical Sciences Sao Paulo State University - UNESP Rodovia Araraquara Jaú, Km 01 - s/n, Campus Ville
Biochemistry Laboratory Department of Clinical Analyses School of Pharmaceutical Sciences Sao Paulo State University - UNESP, Rodovia Araraquara Jaú, Km 01 - s/n, Campus Ville
Cytology and Cellular Biology Laboratory Department of Clinical Analyses School of Pharmaceutical Sciences Sao Paulo State University - UNESP, 1621 Expedicionários do Brasil street, Centro
