Autor(es): Martins, René Duarte ; Jorge, Roberta Jeane Bezerra ; Alves, Renata de Sousa ; Silva Neto, Antônio Gomes da ; Barbosa, Paulo Sergio F. ; Costa Martins, Alice Maria ; Toyama, Marcos H. [UNESP] ; Monteiro, Helena Serra Azul
Data: 2018
Identificador Persistente: http://hdl.handle.net/11449/175060
Origem: Oasisbr
Assunto(s): Bunodosoma caissarum; Endothelin; Envenomation; Isolated perfused kidney; Prostaglandin; Sea anemone
Made available in DSpace on 2018-12-11T17:14:03Z (GMT). No. of bitstreams: 0 Previous issue date: 2017-11-01
Sea anemones contain a variety of interesting biologically active compounds, including some potent toxins. PLA2 from Bunodosoma caissarum, a sea anemone endemic in the Brazilian southern coast, has shown renal alterations on isolated kidney. The aim of this study was to evaluate the renal and vascular effects of B. caissarum crude extract (BcE) on isolated perfused kidney and arteriolar mesenteric bed, as well the involvement of prostaglandins and endothelin. BcE did not show any effect on arteriolar mesenteric bed, but increased perfusion pressure, renal vascular resistance, urinary flow, glomerular filtration rate and decreased the percentage of sodium tubular transport on isolated perfused kidney. Indomethacin blocked the renal effects induced by BcE and tezosentan only partially blocked these effects. These results demonstrate the effects of BcE on kidney in situ, suggesting the involvement of prostaglandins and endothelin.
Department of Nutrition Federal University of Pernambuco CAV
Department of Clinical and Toxicological Analyses Federal University of Ceará
Department of Physiology and Pharmacology Institute of Biomedicine and Clinical Research Unit Federal University of Ceará
Veterinary Faculty State University of Ceará
São Vicente Unit Campus of Litoral Paulista Paulista State University (UNESP)
São Vicente Unit Campus of Litoral Paulista Paulista State University (UNESP)
