Author(s): Fonseca-Santos, Bruno [UNESP] ; Funagoshi, Erica Emi [UNESP] ; de Oliveira, José Ricardo Soares [UNESP] ; do Sacramento, Luis Vitor Silva [UNESP] ; dos Santos, André Gonzaga [UNESP] ; Leonardi, Gislaine Ricci ; Chorilli, Marlus [UNESP]
Date: 2018
Persistent ID: http://hdl.handle.net/11449/175419
Origin: Oasisbr
Subject(s): Liquid crystals/evaluation/physical-chemical stability; Microemulsions/evaluation; Organic cocoa extract; Skin bioadhesion; Surfactant-based system
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Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
This study was to develop, characterize, and evaluate the physical-chemical stability, in vitro antioxidant activity and in vitro safety profile of liquid crystalline systems (LCS) and microemulsions (MEs) with and without organic cocoa (OC) extract. LCS stabilized by surfactant polyoxyethylene 20 cetyl ether, containing water and oleic acid were studied. LCS and MEs were characterized using polarized light microscopy, small angle X-ray scattering, rheology and in vitro bioadhesion, and were evaluated for a period of 30 days by visual aspects, centrifuge test, pH value and relative density. PLM and SAXS assays showed the presence of domains of MEs, cubic and hexagonal mesophasephases, varying the proportions of the components of the formulations; where in the addition of the extract did not change rheological behavior of the formulations. All of the formulations were stable in the period analyzed and presented higher bioadhesive strength. In vitro antioxidant activity suggests that LCS and MEs presented a high capacity to maintain the antioxidant activity of OC extract. The results showed that the incorporation of OC in LCS improved the safety profile, according to cytotoxicity assays of systems may be a promising platform to OC extract for topical application for the potential treatment of skin disorders.
Department of Drugs and Medicines School of Pharmaceutical Sciences São Paulo State University-UNESP
Department of Natural Products and Toxicology School of Pharmaceutical Sciences São Paulo State University-UNESP
Faculty of Pharmaceuticals Sciences University of Campinas-UNICAMP
Department of Drugs and Medicines School of Pharmaceutical Sciences São Paulo State University-UNESP
Department of Natural Products and Toxicology School of Pharmaceutical Sciences São Paulo State University-UNESP
FAPESP: 10/17723-7
