Descrição
Made available in DSpace on 2019-10-06T16:02:52Z (GMT). No. of bitstreams: 0 Previous issue date: 2018-12-01
National Institutes of Health
In Africa, Old World Primates are involved in the maintenance of sylvatic circulation of ZIKV. However, in Brazil, the hosts for the sylvatic cycle remain unknown. We hypothesized that free-living NHPs might play a role in urban/periurban ZIKV dynamics, thus we undertook an NHP ZIKV investigation in two cities in Brazil. We identified ZIKV-positive NHPs and sequences obtained were phylogenetically related to the American lineage of ZIKV. Additionally, we inoculated four C. penicillata with ZIKV and our results demonstrated that marmosets had a sustained viremia. The natural and experimental infection of NHPs with ZIKV, support the hypothesis that NHPs may be a vertebrate host in the maintainance of ZIKV transmission/circulation in urban tropical settings. Further studies are needed to understand the role they may play in maintaining the urban cycle of the ZIKV and how they may be a conduit in establishing an enzootic transmission cycle in tropical Latin America.
São José do Rio Preto School of Medicine (FAMERP) Avenida Brigadeiro Faria Lima 5416 CEP: 15090-000, Vila São Pedro
Laboratório de Vírus - Universidade Federal de Minas Gerais (UFMG) Avenida Antônio Carlos 6627 CEP: 31270-901 Pampulha
Center for Drug Research and Development Instituto de Ciências Biológicas Universidade Federal de Minas Gerais (UFMG) Avenida Antônio Carlos 6627 CEP: 31270-901 Pampulha
Instituto Adolfo Lutz (IAL) Avenida Dr. Arnaldo 351 − 7 Andar Sala 706 CEP: 01246-000 Pacaembú
Laboratory of Wildlife Comparative Pathology Department of Pathology School of Veterinary Medicine and Animal Sciences University of São Paulo (LAPOCM-FMVZ-USP) Avenida Orlando Marques de Paiva 87 CEP: 05508-270
Department of Biology Institute of Biosciences Letters and Exact Sciences – São Paulo State University São José do Rio Preto – (IBILCE/UNESP), Rua Cristóvão Colombo, 2265, CEP: 15054-000
Epidemiological Surveillance Departament of São José do Rio Preto Avenida Romeu Strazzi 199 CEP: 15084-010 Vila Sinibaldi
São Paulo State University (Unesp) Institute for Biotechnology Alameda das Tecomarias s/n CEP: 18607-440 Chácara Capão Bonito
Department of Biochemistry and Molecular Biology University of Texas Medical Branch 301 University Blvd
Centro de Controle de Zoonoses Belo Horizonte Council Rua Édna Quintel 173 CEP: 31270-705 São Bernardo
Faceres Medical School Avenida Anísio Haddad 6751 CEP: 15090-305 Jardim Francisco Fernandes
Department of Epidemiology School of Public Health of the University of São Paulo Avenida Dr. Arnaldo 715 CEP: 01246-904
Department of Pathology and Center of Biodefense and Emerging Infectious Diseases Center for Tropical Diseases Institute for Human Infections and Immunity University of Texas Medical Branch 301 University Blvd
Department of Biology Institute of Biosciences Letters and Exact Sciences – São Paulo State University São José do Rio Preto – (IBILCE/UNESP), Rua Cristóvão Colombo, 2265, CEP: 15054-000
São Paulo State University (Unesp) Institute for Biotechnology Alameda das Tecomarias s/n CEP: 18607-440 Chácara Capão Bonito
National Institutes of Health: R24AI120942
