Autor(es): Laurino, Leticia F. ; Viroel, Fabia J. M. ; Caetano, Erika ; Spim, Sara ; Pickler, Thaisa B. ; Rosa-Castro, Raquel M. ; Vasconcelos, Edilma Albuquerque ; Jozala, Angela F. ; Hataka, Alessandre [UNESP] ; Grotto, Denise ; Gerenutti, Marli
Data: 2020
Identificador Persistente: http://hdl.handle.net/11449/196404
Origem: Oasisbr
Assunto(s): Lentinus edodes; mushroom nutraceuticals; gestational diabetes mellitus; anti-diabetic activity; pre-clinical study
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Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Financiadora de Estudos e Projetos
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Background: The presence of beta-glucans and phenolic compounds in Lentinus edodes suggests this mushroom can be used as a nutritional supplement. Two gestational conditions (before and after fetus implantation) were evaluated, and Lentinus edodes exposure was performed in diabetes mellitus rat model induced by streptozotocin in pre-clinical tests. Methods: On the 20th day of pregnancy, cesarean sections were performed. Blood was collected for biochemical, hematologic parameters and oxidative stress biomarkers. Placenta and amniotic fluid were collected, and fetuses were analyzed through morphological evaluation. Results: The mushroom did not reduce the severe hyperglycemia of the mother-concept but promoted an increase in maternal insulin levels; reduced the levels of alanine aminotransferase, and aspartate aminotransferase, triglyceride and total cholesterol; protected the animals from post-implantation losses. Liver damage induced by streptozotocin was reversed in experimental groups. Conclusions: Lentinus edodes mushroom has antioxidant properties that can minimize the damage caused by gestational diabetes mellitus.
Univ Sorocaba, BR-18023000 Sorocaba, SP, Brazil
Sao Paulo State Univ UNESP, Sch Vet Med & Anim Sci, Dept Vet Clin Sci, BR-18610307 Botucatu, SP, Brazil
Sao Paulo State Univ UNESP, Sch Vet Med & Anim Sci, Dept Vet Clin Sci, BR-18610307 Botucatu, SP, Brazil
FAPESP: 2015/24566-9
FAPESP: 2013/05765-5
Financiadora de Estudos e Projetos: FINEP-01.10.0659.00
