Autor(es): De Oliveira Mantovani, Raíssa ; Pinheiro, Dyovana Gomes ; De Oliveira, Geovana Letícia Fernandes ; Perrud, Stéfani Nobrega ; Teixeira, Giovana Rampazzo [UNESP] ; Nai, Gisele Alborghetti ; Veras, Allice Santos Cruz [UNESP] ; de Almeida Tavares, Maria Eduarda [UNESP] ; de Oliveira Mendes, Leonardo ; Pacagnelli, Francis Lopes
Data: 2020
Identificador Persistente: http://hdl.handle.net/11449/199354
Origem: Oasisbr
Assunto(s): 2,4-Dichlorophenocycetic; Apoptosis; Cardiotoxicity; Herbicide
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The objective of this study was to evaluate the effects of different doses of 2,4-dichlorophenoxyacetic herbicide in rat hearts. Exposure was through rat food that was nebulized with the herbicide. Thirty adult male Wistar rats (200–300 g) were used. The diet was exposed to 2,4-D in two different doses (CG: control group 10 ml distilled water; LCG: low concentration group 3.71 × 10−3 g.ia/ha diluted in 10 ml saline at 0.9% and HCG: High concentration group 9.28 × 10−3 g.ia/ha diluted in 10 ml 0.9% saline). After 6 months of exposure, blood samples were collected for CKMB evaluation, and left ventricular fragments were analyzed by histological evaluation, fibrosis measurements, fractal dimension and immunohistochemistry (BAX, Bcl2, TNF-α and NF-kB). There were no significant changes in CK-MB concentration, histological parameters, fibrosis measurements and fractal dimension. Long-term oral consumption of food nebulized by the herbicide 2,4-D promoted an increase in BAX, Bcl-2/BAX, and cytoplasmic NF-kB in the nuclear area of the group that received the highest dose of the herbicide. This suggests that the herbicide induces cardiotoxicity.
Postgraduate Animal Science Program University of Western São Paulo (UNOESTE)
Faculty of Health Sciences Physiotherapy University of Western São Paulo (UNOESTE)
Faculty of Science and Technology São Paulo State University (UNESP)
Faculty of Science and Technology São Paulo State University (UNESP)
