Author(s):
Souza, Renato T. ; Costa, Maria L. ; Mayrink, Jussara ; Feitosa, Francisco E. ; Filho, Edilberto A. Rocha ; Leite, Débora F. ; Vettorazzi, Janete ; Calderon, Iracema M. [UNESP] ; Sousa, Maria H. ; Passini, Renato ; Baker, Philip N. ; Kenny, Louise ; Cecatti, Jose G. ; Parpinelli, Mary A. ; Fernandes, Karayna G. ; Galvão, Rafael B. ; Guida, José Paulo ; Santana, Danielly S. ; Franchini, Kleber G. ; Cassettari, Bianca F. [UNESP] ; Pfitscher, Lucia ; Brust, Luiza ; Melo, Elias F. ; Anacleto, Danilo ; de Lucena, Daisy ; Sousa, Benedita
Date: 2020
Persistent ID: http://hdl.handle.net/11449/199965
Origin: Oasisbr
Description
Made available in DSpace on 2020-12-12T01:54:02Z (GMT). No. of bitstreams: 0 Previous issue date: 2020-12-01
The objective of this study was to determine incidence and risk factors associated with spontaneous preterm birth (sPTB). It was a prospective multicentre cohort study performed in five Brazilian referral maternity hospitals and enrolling nulliparous women at 19–21 weeks. Comprehensive maternal data collected during three study visits were addressed as potentially associated factors for sPTB. Bivariate and multivariate analysis estimated risk ratios. The main outcomes measures were birth before 37 weeks due to spontaneous preterm labour or premature rupture of membranes (sPTB). The comparison group was comprised of women with term births (≥37weeks). Outcome data was available for 1,165 women, 6.7% of whom had sPTB, 16% had consumed alcohol and 5% had used other illicit drugs during the first half of pregnancy. Current drinking at 19–21 weeks (RR 3.96 95% CI [1.04–15.05]) and a short cervix from 18–24 weeks (RR 4.52 95% CI [1.08–19.01]) correlated with sPTB on bivariate analysis. Increased incidence of sPTB occurred in underweight women gaining weight below quartile 1 (14.8%), obese women gaining weight above quartile 3 (14.3%), women with a short cervix (<25 mm) at 18–24 weeks (31.2%) and those with a short cervix and vaginal bleeding in the first half of pregnancy (40%). Cervical length (RRadj 4.52 95% CI [1.08–19.01]) was independently associated with sPTB. In conclusion, the incidence of sPTB increased in some maternal phenotypes, representing potential groups of interest, the focus of preventive strategies. Similarly, nulliparous women with a short cervix in the second trimester require further exploration.
Department of Obstetrics and Gynaecology University of Campinas (UNICAMP) School of Medical Sciences
MEAC – School Maternity of the Federal University of Ceará
Department of Maternal and Child Health Clinics Hospital Federal University of Pernambuco
Department of Obstetrics and Gynaecology Maternity of the Clinics Hospital Federal University of RS
Department of Obstetrics and Gynaecology Botucatu Medical School Unesp
Statistics Unit Jundiai School of Medicine
College of Life Sciences University of Leicester
Faculty of Health and Life Sciences University of Liverpool
LNBio
Department of Obstetrics and Gynaecology Botucatu Medical School Unesp
