Autor(es): Souza, Maurício Palmeira Chaves de [UNESP] ; Sábio, Rafael Miguel [UNESP] ; Ribeiro, Tais de Cassia [UNESP] ; Santos, Aline Martins dos [UNESP] ; Meneguin, Andréia Bagliotti [UNESP] ; Chorilli, Marlus [UNESP]
Data: 2020
Identificador Persistente: http://hdl.handle.net/11449/200530
Origem: Oasisbr
Assunto(s): Biopolymer; Chitosan; Drug delivery systems; Gastroretentive systems; Stomach
Made available in DSpace on 2020-12-12T02:09:03Z (GMT). No. of bitstreams: 0 Previous issue date: 2020-09-15
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
The development of gastroretentive systems have been growing lately due to the high demand for carriers that increase drug bioavailability and therapeutic effectiveness after oral administration. Most of systems reported up to now are based on chitosan (CS) due to its peculiar properties, such as cationic nature, biodegradability, biocompatibility and important mucoadhesiveness, which make CS a promising biopolymer to design effective gastroretentive systems. In light of this, we reported in this review the CS versatility to fabricate different types of nano- and microstructured gastroretentive systems. For a better understanding of the gastric retention mechanisms, we highlighted expandable, density-based, magnetic, mucoadhesive and superporous systems. The biological and chemical properties of CS, anatomophysiological aspects related to gastrointestinal tract (GIT) and some applications of these systems are also described here. Overall, this review may assist researchers to explore new strategies to design safe and efficient gastroretentive systems in order to popularize them in the treatment of diseases and clinical practices.
São Paulo State University (UNESP) School of Pharmaceutical Sciences Araraquara Department of Drugs and Medicines, Rodovia Araraquara-Jaú, km 1, - Campos Ville
São Paulo State University (UNESP) School of Pharmaceutical Sciences Araraquara Department of Drugs and Medicines, Rodovia Araraquara-Jaú, km 1, - Campos Ville
FAPESP: 2014/50928-2
CNPq: 465687/2014-8
CAPES: 88887.199954/2018-00
