Author(s): de Araújo, Erivelto Corrêa [UNESP] ; Garcia, Leandro Encarnação [UNESP] ; Araújo, Matheus Janeck [UNESP] ; Oliveira-Junior, Itamar Souza ; Arnold, Daniel Robert [UNESP] ; Lopes, Flavia Lombardi [UNESP] ; Marinho, Márcia [UNESP]
Date: 2020
Persistent ID: http://hdl.handle.net/11449/201380
Origin: Oasisbr
Made available in DSpace on 2020-12-12T02:31:03Z (GMT). No. of bitstreams: 0 Previous issue date: 2019-12-01
Leptospira genus contains species that affect human health with varying degrees of pathogenicity. In this context, we aimed to evaluate the differences in the modulation of host gene expression by strains of Leptospira varying in virulence. Our data showed a high number of differentially expressed transcripts in murine macrophages following 6h of infection. Leptospira infection modulated a set of genes independently of their degree of virulence. However, pathway analysis indicated that Apoptosis, ATM Signaling, and Cell Cycle: G2/M DNA Damage Checkpoint Regulation were exclusively regulated following infection with the virulent strain. Taken together, results demonstrated that species and virulence play a role during host response to Leptospira spp in murine macrophages, which could contribute to understanding the pathogenesis of leptospirosis.
Department of Production and Animal Health São Paulo State University (Unesp) School of Veterinary Medicine
Department of Surgery Discipline of Anesthesia Pain and Intensive Medicine Federal University of São Paulo
Department of Production and Animal Health São Paulo State University (Unesp) School of Veterinary Medicine
