Author(s): Ferreira, Patrícia Osório [UNESP] ; de Moura, Aniele [UNESP] ; de Almeida, Amanda Cosmo [UNESP] ; dos Santos, Éverton Carvalho [UNESP] ; Kogawa, Ana Carolina ; Caires, Flávio Junior [UNESP]
Date: 2021
Persistent ID: http://hdl.handle.net/11449/206024
Origin: Oasisbr
Subject(s): Mechanochemical synthesis; Norfloxacin; Pharmaceutical cocrystal; Saccharin; Solvate; Thermal analysis
Made available in DSpace on 2021-06-25T10:25:15Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-01-01
Cocrystallization is a very efficient strategy to improve the physicochemical properties of bioactive agents. A new norfloxacin (NOR)–saccharin cocrystal and a cocrystal–solvate were synthesized through the mechanochemical method (neat and liquid-assisted grinding), and the characterization was performed by thermal analysis (TG–DTA, DSC and DSC microscopy), infrared vibrational spectroscopy and powder X-ray diffraction. Moreover, solubility experiments carried out in water and buffer solutions (pH 3.0, 6.1 and 8.5) showed that norfloxacin has an aqueous solubility 3.5 times higher when cocrystallized with saccharin than in its pristine state, and an inverted pH-dependency compared to NOR alone (2 times higher in 6.1, slightly increase in pH 3.0, and a decrease of 0.7 times in 8.5 buffer solution). Furthermore, the solvate–cocrystal has a water solubility 2.3 times higher than NOR and the same solubility in 6.1 buffer solution than the cocrystal (2 times higher than NOR alone).
São Paulo State University (UNESP) Institute of Chemistry
School of Science Chemistry Department São Paulo State University (UNESP)
Federal University of Goias (UFG) School of Pharmacy
São Paulo State University (UNESP) Institute of Chemistry
School of Science Chemistry Department São Paulo State University (UNESP)
