Author(s): Bagagli, Eduardo [UNESP] ; Matute, Daniel Ricardo ; Garces, Hans Garcia [UNESP] ; Tenório, Bernardo Guerra ; Garces, Adalberto Garcia [UNESP] ; Alves, Lucas Gomes de Brito ; Yamauchi, Danielle Hamae [UNESP] ; Hrycyk, Marluce Francisca ; Barker, Bridget Marie ; Teixeira, Marcus de Melo
Date: 2021
Persistent ID: http://hdl.handle.net/11449/207177
Origin: Oasisbr
Subject(s): Admixture; Amazon; Armadillos; Paracoccidioides; Paracoccidioidomycosis
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Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
National Institute of Allergy and Infectious Diseases
National Institutes of Health
National Institute of General Medical Sciences
Paracoccidioidomycosis is an endemic fungal disease to Latin America caused by at least five species-level genotypes of Paracoccidioides, named P. lutzii, P. brasiliensis (S1a and S1b populations), P. americana, P. restrepiensis, and P. venezuelensis. In this manuscript, we report on Paracoccidioides sp. sampling efforts in armadillos from two different areas in Brazil. We sequenced the genomes of seven Paracoccidioides isolates and used phylogenomics and populations genetics for genotyping. We found that P. brasiliensis and P. lutzii are both present in the Amazon region. Additionally, we identified two Paracoccidioides isolates that seem to be the result of admixture between divergent populations within P. brasiliensis sensu stricto. Both of these isolates were recovered from armadillos in a P. lutzii endemic area in Midwestern Brazil. Additionally, two isolates from human patients also show evidence of resulting from admixture. Our results suggest that the populations of P. brasiliensis sensu stricto exchange genes in nature. More generally, they suggest that population structure and admixture within species is an important source of variation for pathogenic fungi.
Departamento de Microbiologia e Imunologia Instituto de Biociências de Botucatu Universidade Estadual Paulista/UNESP
Department of Biology University of North Carolina
Faculdade de Medicina Universidade de Brasília, DF
Faculdade de Ciências Biológicas e Agrárias Universidade do Estado de Mato Grosso, Campus de Alta Floresta
Pathogen and Microbiome Institute Northern Arizona University
Departamento de Microbiologia e Imunologia Instituto de Biociências de Botucatu Universidade Estadual Paulista/UNESP
FAPESP: 2018/06390-9
CNPq: 460999/2014-1
National Institute of Allergy and Infectious Diseases: ADHS16-162415
National Institutes of Health: ADHS16-162415
National Institute of Allergy and Infectious Diseases: ADHS17-0007403
National Institutes of Health: ADHS17-0007403
National Institute of General Medical Sciences: R01GM121750
National Institutes of Health: R01GM121750
National Institute of Allergy and Infectious Diseases: R21AI28536
National Institutes of Health: R21AI28536
