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Li Ka Shing Foundation
Medical Research Council
National Institute for Health Research
Nuffield College, University of Oxford
Dexamethasone can reduce mortality in hospitalised COVID-19 patients needing oxygen and ventilation by 18% and 36%, respectively. Here, we estimate the potential number of lives saved and life years gained if this treatment were to be rolled out in the UK and globally, as well as the cost-effectiveness of implementing this intervention. Assuming SARS-CoV-2 exposure levels of 5% to 15%, we estimate that, for the UK, approximately 12,000 (4,250 - 27,000) lives could be saved between July and December 2020. Assuming that dexamethasone has a similar effect size in settings where access to oxygen therapies is limited, this would translate into approximately 650,000 (240,000 - 1,400,000) lives saved globally over the same time period. If dexamethasone acts differently in these settings, the impact could be less than half of this value. To estimate the full potential of dexamethasone in the global fight against COVID-19, it is essential to perform clinical research in settings with limited access to oxygen and/or ventilators, for example in low- and middle-income countries.
Mahidol-Oxford Tropical Medicine Research Unit Nuffield Department of Medicine University of Oxford
Institute of Biomedical Engineering Department of Engineering Science University of Oxford
Big Data Institute Li Ka Shing Centre for Health Information and Discovery Nuffield Department of Medicine University of Oxford
Centre for Tropical Medicine and Global Health Nuffield Department of Medicine University of Oxford
Medical Research Council Population Health Research Unit at the University of Oxford Nuffield Department of Population Health
World Health Organization
Public Fund “Institution of social development” in the Kyrgyz Republic
Department of Paediatrics Faculty of Medicine Universitas Sumatera Utara
Universidade da Paz
USAID Mission in the Kyrgyz Republic
Institute of Health Policy Management and Evaluation University of Toronto
Oxford Policy Management
Department of Mathematics Federal University
Stop Transmission of Polio Program (STOP) program World Health Organization
Institute of Research and Education Development University of Health Sciences
Laboratory for Public Health Research biotechnology Biotechnology Center University of Yaounde
London School of Economics
Department of Medicine Weill Cornell Medicine and Cornell Institute for Disease and Disaster Preparedness Cornell University
Mathematical And Economic MODelling Group Mahidol-Oxford Tropical Medicine Research Unit Faculty of Tropical Medicine Mahidol University
Health Intervention and Technology Assessment Program (HITAP) Ministry of Public Health
COVID-19 Task Force for North Sumatera province
Department of Epidemiology and Biostatistics Research Centre for Emerging and Reemerging Infectious Diseases Pasteur Institute of Iran
Center for Mathematics Computation and Cognition Federal University of ABC
Nuffield Department of Medicine University of Oxford
Ministry of Public Health of the Kyrgyz Republic
Universidade Nacional Timor Lorosae
Menzies School of Health Research Charles Darwin University
Independent researcher (no affiliation)
University of Nottingham
Population Services International
Department of Community Medicine Faculty of Medicine Universitas Sumatera Utara
Government of People’s Republic of Bangladesh
Department of Research Development and Innovation University of Malaya Medical Centre
Department of Statistics Payame Noor University
Ministry of Public Health
Malawi Ministry of Health
Centro de Simulacion y Modelos (CeSiMo) Universidad de Los Andes
HIV/STI Surveillance Research Center and WHO Collaborating Center for HIV Surveillance Institute for Futures Studies in Health Kerman University of Medical Sciences
Medical Association in the Kyrgyz Republic
Department of Biostatistics Kermanshah University of Medical Sciences
University of Malaya
Institute for Theoretical Physics São Paulo State University (UNESP)
University College of London
Valid International Ltd
Soros Foundation in the Kyrgyz Republic
Ministry of Health Timor-Leste
PEAK Urban and Oxford Martin Informal Cities Programmes COMPAS School of Anthropology and Museum Ethnography University of Oxford
Faculty of Pharmacy University of Malaysia
Institute of Health Economics University of Dhaka
Department of Social and Preventive Medicine Faculty of Medicine University of Malaya
Department of Marketing & Business Analytics Lucas College and Graduate School of Business San José State University
Department of Epidemiology and Biostatistics College of Public Health University of the Philippines Manila
Fiji Center for Disease Control (CDC)
Institute for Theoretical Physics São Paulo State University (UNESP)
Nuffield College, University of Oxford: COVID-19 Research Response Fund
