Author(s):
Della Coletta, Bruna Botteon ; Jacob, Thiago Borges ; Moreira, Luana Aparecida de Carvalho ; Pomini, Karina Torres ; Buchaim, Daniela Vieira [UNESP] ; Eleutério, Rachel Gomes ; Pereira, Eliana de Souza Bastos Mazuqueli ; Roque, Domingos Donizeti ; Rosso, Marcelie Priscila de Oliveira ; Shindo, João Vitor Tadashi Cosin ; Duarte, Marco Antônio Húngaro ; Alcalde, Murilo Priori ; Júnior, Rui Seabra Ferreira [UNESP] ; Barraviera, Benedito [UNESP] ; Dias, Jefferson Aparecido ; Andreo, Jesus Carlos ; Buchaim, Rogério Leone [UNESP]
Date: 2021
Persistent ID: http://hdl.handle.net/11449/207323
Origin: Oasisbr
Subject(s): biomaterials; bone regeneration; fibrin biopolymer; low-level laser therapy; photobiomodulation therapy
Description
Made available in DSpace on 2021-06-25T10:53:11Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-02-05
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
The aim is to evaluate the effects of photobiomodulation therapy (PBMT) on the guided bone regeneration process (GBR) in defects in the calvaria of rats filled with biphasic calcium phosphate associated with fibrin biopolymer. Thirty male Wistar rats were randomly separated: BMG (n = 10), defects filled with biomaterial and covered by membrane; BFMG (n = 10), biomaterial and fibrin biopolymer covered by membrane; and BFMLG (n = 10), biomaterial and fibrin biopolymer covered by membrane and biostimulated with PBMT. The animals were euthanized at 14 and 42 days postoperatively. Microtomographically, in 42 days, there was more evident bone growth in the BFMLG, limited to the margins of the defect with permanence of the particles. Histomorphologically, an inflammatory infiltrate was observed, which regressed with the formation of mineralized bone tissue. In the quantification of bone tissue, all groups had a progressive increase in new bone tissue with a significant difference in which the BFMLG showed greater bone formation in both periods (10.12 ± 0.67 and 13.85 ± 0.54), followed by BFMG (7.35 ± 0.66 and 9.41 ± 0.84) and BMG (4.51 ± 0.44 and 7.11 ± 0.44). Picrosirius-red staining showed greater birefringence of collagen fibers in yellow-green color in the BFMLG, showing more advanced bone maturation. PBMT showed positive effects capable of improving and accelerating the guided bone regeneration process when associated with biphasic calcium phosphate and fibrin biopolymer.
Department of Biological Sciences (Anatomy) Bauru School of Dentistry University of São Paulo (USP)
Medical and Dentistry School University of Marilia (UNIMAR)
Postgraduate Program in Structural and Functional Interactions in Rehabilitation University of Marilia (UNIMAR)
Medical School University Center of Adamantina (UniFAI)
Center for the Study of Venoms and Venomous Animals (CEVAP) São Paulo State University (Univ Estadual Paulista
Department of Dentistry Endodontics and Dental Materials Bauru School of Dentistry University of São Paulo (USP)
Department of Health Science Unisagrado University Center
Graduate Program in Tropical Diseases Botucatu Medical School (FMB) São Paulo State University (UNESP - Univ Estadual Paulista)
Graduate Program in Clinical Research Center for the Study of Venoms and Venomous Animals (CEVAP) São Paulo State University (UNESP-Univ Estadual Paulista)
Postgraduate Program in Law University of Marilia (UNIMAR)
Center for the Study of Venoms and Venomous Animals (CEVAP) São Paulo State University (Univ Estadual Paulista
Graduate Program in Tropical Diseases Botucatu Medical School (FMB) São Paulo State University (UNESP - Univ Estadual Paulista)
Graduate Program in Clinical Research Center for the Study of Venoms and Venomous Animals (CEVAP) São Paulo State University (UNESP-Univ Estadual Paulista)
CAPES: The present study was financed in part by the Coordenação
