Autor(es):
Machado, Flávia Danniele Frota ; Formiga, Rodrigo de Oliveira ; Lima, Gedson Rodrigues de Morais ; de Jesus, Neyres Zínia Taveira ; Alves Júnior, Edvaldo Balbino ; Marinho, Alexsandro Fernandes ; Tavares, Josean Fechine ; Santos, Flávia Almeida ; Viana, Ana Flávia Seraine Custódio ; Araújo, Aurigena Antunes ; de Araújo Júnior, Raimundo Fernandes ; Pellizzon, Cláudia Helena [UNESP] ; Batista, Leônia Maria
Data: 2021
Identificador Persistente: http://hdl.handle.net/11449/208021
Origem: Oasisbr
Assunto(s): Hyptis suaveolens; Intestinal anti-inflammatory activity; Medicinal plant
Descrição
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Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Ethnopharmacological relevance: In folk medicine Hyptis suaveolens (Lamiaceae) has been reported to relieve respiratory and gastrointestinal infections, indigestion, cold, pain, fever, cramps, skin diseases, gastric ulcer and inflammatory disorders. This study investigated the effects and the mechanisms of action of Hyptis suaveolens (L.) Poit (Lamiaceae) ethanol extract (Hs-EtOH) and hexane phase (Hs-HexF) against intestinal inflammation. Material and methods: Acute and relapse TNBS-induced ulcerative colitis protocols were used to evaluate intestinal anti-inflammatory activity. Damage evaluations, biochemical, histological and immunostaining parameters were determined. Results: Both extracts decreased macroscopic colonic inflammation and the area of lesion induced by TNBS. Nevertheless, only Hs-HexF was able to reduce colonic wall thickness, edema and diffuse inflammatory cell infiltration and to prevent GSH depletion in the acute model of ulcerative colitis. In the chronic phase with relapse of colonic ulceration, yet again only Hs-HexF significantly attenuated inflammatory parameters and presented a decrease in nitrite/nitrate, MDA, MPO, IL-1-β and TNF-α and increased levels of SOD, CAT, GSH and IL-10. Hs-HexF also significantly reduced positive cells immunostained for PCNA. Conclusion: The data indicate intestinal anti-inflammatory activity for H. suaveolens, due to the participation of the antioxidant system, decreased neutrophil infiltration and cytokine modulation, as well as, owing to regulation of cell proliferation.
Postgraduate Program in Natural and Synthetic Bioactive Products Health Sciences Center Universidade Federal da Paraíba (UFPB)
Laboratory of Natural Products Universidade Federal do Ceará (UFC)
Department of Biophysics and Pharmacology Universidade Federal do Rio Grande Norte (UFRN)
Department of Morphology Histology and Basic Pathology Federal University of Rio Grande do Norte
Laboratory of Histology UNIPEX-FMB Universidade de São Paulo (UNESP)
Laboratory of Histology UNIPEX-FMB Universidade de São Paulo (UNESP)
CNPq: 14/2014
