Autor(es): dos Santos, Paulo Victor P. ; Ribeiro, Camila M. [UNESP] ; Pavan, Fernando R. [UNESP] ; Corbi, Pedro P. ; Bergamini, Fernando R.G. ; Carvalho, Marcos A. ; D'Oliveria, Kaique A. ; Cuin, Alexandre
Data: 2021
Identificador Persistente: http://hdl.handle.net/11449/208478
Origem: Oasisbr
Assunto(s): Mycobacterium tuberculosis; N-acylhydrazones; Powder X-ray diffraction; Silver complexes
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Fundação de Amparo à Pesquisa do Estado de Minas Gerais (FAPEMIG)
In the present work, synthesis, characterization and antitubercular assays of N-acylhydrazones derivatives and their corresponding silver(I) complexes are described. The compounds were characterized by elemental analysis, IR and NMR spectroscopic measurements, molar conductivity assays and powder diffraction X ray studies. Some of the synthesized compounds have shown minimum inhibitory concentration (MIC90) values against M. tuberculosis H37Rv (ATCC 27294) lower than 0.098 µg/mL, while the cytotoxic activity assays over MRC-5 cells reveled that all compounds present selectivity indexes higher than 27. Furthermore, N-acylhydrazones compounds showed promising activities even against multidrug-resistant clinical strains of M. tuberculosis.
LQBin – Laboratory of BioInorganic Chemistry Chemistry Department Institute of Exact Sciences Federal University of Juiz de Fora – UFJF
São Paulo State University (UNESP) School of Pharmaceutical Sciences Tuberculosis Research Laboratory Araraquara
Institute of Chemistry University of Campinas – UNICAMP
Laboratory of Synthesis of Bioinspired Molecules Institute of Chemistry Federal University of Uberlândia – UFU
Chemistry Department Federal University of Mato Grosso – UFMT
São Paulo State University (UNESP) School of Pharmaceutical Sciences Tuberculosis Research Laboratory Araraquara
FAPEMIG: 2018
