Autor(es):
Amorim, Marcelo R. de [UNESP] ; Paz, Tiago A. [UNESP] ; Pinto, Luciano da S. ; Hilario, Felipe [UNESP] ; Zanini, Camila L. ; Aguiar, Anna Caroline C. ; Silva, Debora E. S. [UNESP] ; Furlan, Maysa [UNESP] ; Guido, Rafael V. C. ; Bauab, Tais M. [UNESP] ; Netto, Adelino V. de G. [UNESP] ; Santos, Lourdes C. dos [UNESP]
Data: 2022
Identificador Persistente: http://hdl.handle.net/11449/218953
Origem: Oasisbr
Assunto(s): Isoquinoline; Endophytic fungus; Paraphaeosphaeria sporulosa; Paepalanthus planifolius; Eriocaulaceae
Descrição
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Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
As part of our continuing efforts to discover new bioactive compounds from endophytic fungal sources, we have investigated the extract of the Paraphaeosphaeria sporulosa F03 strain. The study led to the isolation of four new 3-methyl-isoquinoline alkaloids ( 1 - 4 ) and four known polyketides ( 5 - 8 ). The structures of compounds 1 - 4 were elucidated by 1D and 2D NMR experiments and HRMS analysis. The absolute configuration of 4 was determined by comparison of its experimental electronic circular dichroism spectrum with calculated data. Compounds 1 - 4 exhibited antifungal activity with minimal inhibitory concentration values ranging from 6.25 - 50 mu g/mL against six Candida species but they did not present any cytotoxic activity against the human tumor cell lines A549 (lung), MCF-7 (breast), and HepG2 (hepatocellular). In addition, compound 4 exhibited antiplasmodial activity in the low micromolar range (IC (50) = 4 mu M).
Sao Paulo State Univ Unesp, Inst Chem, Rua Francisco Degni S-N, BR-14800900 Araraquara, SP, Brazil
Fed Univ Sao Carlos UFSCar, Dept Chem, Sao Carlos, SP, Brazil
Sao Paulo State Univ Unesp, Sch Pharmaceut Sci, Araraquara, SP, Brazil
Univ Sao Paulo, Sao Carlos Inst Phys, Sao Carlos, SP, Brazil
Sao Paulo State Univ Unesp, Inst Chem, Rua Francisco Degni S-N, BR-14800900 Araraquara, SP, Brazil
Sao Paulo State Univ Unesp, Sch Pharmaceut Sci, Araraquara, SP, Brazil
FAPESP: 2015/11058-5
FAPESP: 2015/04899-3
FAPESP: 2020/01193-0
FAPESP: 2013/07600-3
FAPESP: 2020/12904-5
FAPESP: 2016/17711-5
CAPES: 001
