Autor(es): de Morandim-Giannetti, Andreia A. [UNESP] ; Cotinguiba, Fernando [UNESP] ; Regasini, Luis O. [UNESP] ; Frigieri, Mariana C. [UNESP] ; Varanda, Eliana A. [UNESP] ; Coqueiro, Aline [UNESP] ; Kato, Massuo J. ; Bolzani, Vanderlan S. [UNESP] ; Furlan, Maysa [UNESP]
Data: 2022
Identificador Persistente: http://hdl.handle.net/11449/226393
Origem: Oasisbr
Assunto(s): (z)-piplartine; Ames test; Mutagenic activated; Piper tuberculatum; Piperaceae
Made available in DSpace on 2022-04-28T22:48:46Z (GMT). No. of bitstreams: 0 Previous issue date: 2011-06-15
Phytochemical studies carried out with Piperaceae species have shown great diversity of secondary metabolites among which are several displayed considerable biological activities. The species Piper tuberculatum has been intensively investigated and a series of amides have been described. For instance, (E)-piplartine showed significant cytotoxic activity against tumor cell lines, especially human leukemia cell lines; antifungal activity against Cladosporium species; trypanocidal activity and others. Considering the popular use of P. tuberculatum and the lack of pharmacological studies regarding this plant species, the mutagenic and antimutagenic effect of (Z)-piplartine was evaluated by the Ames test, using the strains TA97a, TA98, TA100 and TA102 of Salmonella typhimurium. No mutagenic activity was observed for this compound. © 2011 Academic Journals.
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Departamento de Química Fundamental Instituto de Química Universidade de São Paulo, Av. Prof. Lineu Prestes, 748, 05508-000, São Paulo-SP
Departamento de Química Orgânica Instituto de Química Universidade Estadual de São Paulo, Rua Francisco Degni, s/n, 14800-900 Araraquara-SP
Departamento de Ciências Biológicas Faculdade de Ciências Farmacêuticas Universidade Estadual Paulista, Rodovia Araraquara/Jaú Km 1, 14801-902 Araraquara-SP
