Descrição
Made available in DSpace on 2022-04-29T08:40:33Z (GMT). No. of bitstreams: 0 Previous issue date: 2022-03-01
Myocardial infarction has a high mortality rate worldwide. Therefore, clinical intervention in cardiac remodeling after myocardial infarction is essential. Ac¸ai pulp is a natural product and has been considered a functional food because of its antioxidant/anti-inflammatory properties. The aim of the present study was to analyze the effect of ac¸ai pulp supplementation on cardiac remodeling after myocardial infarction in rats. After 7 days of surgery, male Wistar rats were assigned to six groups: sham animals fed standard chow (SA0, n = 14), fed standard chow with 2% ac¸ai pulp (SA2, n = 12) and fed standard chow with 5% ac¸ai pulp (SA5, n = 14), infarcted animals fed standard chow (IA0, n = 12), fed standard chow with 2% ac¸ai pulp (IA2, n = 12), and fed standard chow with 5% ac¸ai pulp (IA5, n = 12). After 3 months of supplementation, echocardiography and euthanasia were performed. Ac¸ai pulp supplementation, after myocardial infarction, improved energy metabolism, attenuated oxidative stress (lower concentration of malondialdehyde, P = 0.023; dose-dependent effect), modulated the inflammatory process (lower concentration of interleukin-10, P0.001; dose-dependent effect) and decreased the deposit of collagen (lower percentage of interstitial collagen fraction, P0.001; dose-dependent effect). In conclusion, ac¸ai pulp supplementation attenuated cardiac remodeling after myocardial infarction in rats. Also, different doses of ac¸ai pulp supplementation have dose-dependent effects on cardiac remodeling.
Internal Medicine Department Botucatu Medical School Universidade Estadual Paulista (UNESP), São Paulo
Chemistry and Biochemistry Department Institute of Biosciences Universidade Estadual Paulista (UNESP), São Paulo
Internal Medicine Department Botucatu Medical School Universidade Estadual Paulista (UNESP), São Paulo
Chemistry and Biochemistry Department Institute of Biosciences Universidade Estadual Paulista (UNESP), São Paulo
