Autor(es):
de Moura, Aniele [UNESP] ; Gaglieri, Caroline [UNESP] ; Alarcon, Rafael Turra [UNESP] ; Ferreira, Laura Teófilo [UNESP] ; Vecchi, Rafael [UNESP] ; Sanches, Mariana Liessa Rovis ; de Oliveira, Rodrigo Cardoso ; Venturini, James [UNESP] ; da Silva-Filho, Luiz Carlos [UNESP] ; Junior Caires, Flávio [UNESP]
Data: 2022
Identificador Persistente: http://hdl.handle.net/11449/231546
Origem: Oasisbr
Assunto(s): Biological activity; Curcuminoids; Mechanochemistry; Multicomponent reactions; Sustainable chemistry.
Descrição
Made available in DSpace on 2022-04-29T08:46:04Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-11-08
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Over the years, several drugs have been developed deriving from plants to investigate possible therapeutic roles. Among them, curcuminoids and coumarins, which, display a wide range of biological activity against several strains. Therefore, it was synthesized a curcuminoids-coumarin derivative by a mechanochemical multicomponent reaction. By NMR and HRMS results confirmed the formation of a mixture of three curcuminoids-coumarin derivatives in the same sample. The Influence of time during the milling process was evaluated, resulting in a crystalline product in only 30 min. The LAG milling carried out with different solvents showed that the product is obtained regardless of the solvent polarity. Furthermore, the biological evaluation showed that the curcuminoids-coumarin derivative has better activity against S. aureus than curcumin and 4-hydroxycoumarin. Lastly, the cell viability study exhibited a decrease of cytotoxicity of the derivative, compared to curcumin, against NIH3T3 cells.
School of Sciences Chemistry Department UNESP São Paulo State University
Institute of Chemistry UNESP-São Paulo State University
Medicine School Tropical Diseases and Imaging Diagnosis UNESP-São Paulo State University
Bauru School of Dentistry Department of Biological Sciences USP-University of São Paulo
Medicine School UFMS- Mato Grosso do Sul Federal University
School of Sciences Chemistry Department UNESP São Paulo State University
Institute of Chemistry UNESP-São Paulo State University
Medicine School Tropical Diseases and Imaging Diagnosis UNESP-São Paulo State University
CAPES: 024/2012 Pro-equipment
