Microbiological assay for lomefloxacin in coated tablets

• Autor(es): Gomes, Greici Cristiani [UNESP] ; Salgado, Hérida Regina Nunes [UNESP]
• Data: 2022
• Identificador Persistente: http://hdl.handle.net/11449/231800
• Origem: Oasisbr
• Tipo de Documento: Artigo científico
• Idioma: Inglês

Descrição

Made available in DSpace on 2022-04-29T08:47:28Z (GMT). No. of bitstreams: 0 Previous issue date: 2006-01-01

The validation of a microbiological assay, applying cylinder plate method for determination of the activity of lomefloxacin in coated tablets is described. Using a strain of Bacillus subtilis ATCC 9372 as the test organism, lomefloxacin was measured in concentrations ranging from 2.0 to 8.0 μg/mL. The method validation showed that it is linear (r= 0.9999), precise (relative standard deviation = 1.15%), and accurate (it measured the added quantities). The excipients did not interfere in the determination. It was concluded that the microbiological assay is satisfactory for quantitation of lomefloxacin in tablets.

Universidade Estadual Paulista (UNESP) Faculdade de Ciências Farmacêuticas UNESP, Rod. Araraquara-Jaú, km 1, CEP 14801-902, Araraquara, SP

Universidade Estadual Paulista (UNESP) Faculdade de Ciências Farmacêuticas UNESP, Rod. Araraquara-Jaú, km 1, CEP 14801-902, Araraquara, SP