Author(s): Carli, Camila B. de A. [UNESP] ; Quilles, Marcela Bassi [UNESP] ; Vilegas, Wagner [UNESP] ; Carlos, Iracilda Z. [UNESP]
Date: 2022
Persistent ID: http://hdl.handle.net/11449/232148
Origin: Oasisbr
Subject(s): Cancer; Macrophages; Q. multiflora
Made available in DSpace on 2022-04-29T08:49:20Z (GMT). No. of bitstreams: 0 Previous issue date: 2013-09-01
Species of the genus Qualea are used by the Brazilian public as a natural anti-inflammatory. Based on this evidence, we evaluated the effects of terpene fractions (βF and TF) obtained from Qualea multiflora on nitric oxide production (Griess assay), cytokines (IL-1, IL-10, IL-12, and TNF-α) and the transcription factor NF-KB by peritoneal macrophages. Since there is a relationship between inflammation and cancer, the cytotoxicity of βF and TF against mammary tumoural cell lineage, and macrophages was evaluated. Inhibition levels close to 90% of the production of NO, IL-1, IL-12 and TNF-α; about 32% of NF-KB; and a large stimulation of IL-10 production (close to the positive control) by peritoneal macrophages were observed in response to βF and TF which are correlated with anti-inflammatory activity. Additionally, the samples showed exceptional cytotoxic activity against tumoural cells but not against macrophages. Since anti-inflammatory activity is important in tumour inhibition, further examination of potential anti-cancerous activity of Qualea multiflora is warranted. © 2013 Camila B. de A. Carli et al.
UNESP - São Paulo State University Faculdade de Ciências Farmacêuticas, C. Postal 502, 14801-902, Araraquara, SP
UNESP - São Paulo State University Instituto de Química de Araraquara, C. Postal 355, 14801-970, Araraquara, SP
UNESP - São Paulo State University Faculdade de Ciências Farmacêuticas, C. Postal 502, 14801-902, Araraquara, SP
UNESP - São Paulo State University Instituto de Química de Araraquara, C. Postal 355, 14801-970, Araraquara, SP
