Author(s): do Nascimento, Patrícia Aleixa [UNESP] ; Kogawa, Ana Carolina [UNESP] ; Salgado, Hérida Regina Nunes [UNESP]
Date: 2022
Persistent ID: http://hdl.handle.net/11449/233170
Origin: Oasisbr
Subject(s): Green analytical chemistry; Infrared spectrometric method; Pharmaceutical analysis; Sustainable alternative; Vancomycin
Made available in DSpace on 2022-05-01T05:29:27Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-01-01
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Fundação Cearense de Apoio ao Desenvolvimento Científico e Tecnológico
Universidade Estadual Paulista
Governo Brasil
Vancomycin, an antimicrobial, does not present quantitative method by infrared spectrometry in the literature for the evaluation of a pharmaceutical product. This technique is considered a clean alternative because in the main, there is no solvent involved and the generation of waste is reduced. So, the aim of this study was to develop and validate a new, ecological, low cost and fast method by infrared spectrometry using KBr and band between 1450-1375 cm-1. It was linear in the range of 1.0-2.0 mg/150 mg, with a correlation coefficient of 0.9994. Selective when the spectra of vancomycin reference and sample were compared. Precise by repeatability (2.29%) and intermediate precision (3.12%). Accurate with average recovery of 99.37% and robust when strength and compression time of the pellets and KBr brand were varied. Considering all the methods found in literature, there is not one using infrared spectrometry for quantitative purpose, so the method developed and validated could be considered an innovation and clean alternative. This is due to the fact that it is fast, easy to handle, low cost, and non-toxic as well as generating minimal waste. The method can be applied in the routine analysis of vancomycin dosage form and is an important option for the current and sustainable pharmaceutical analysis.
Department of Pharmaceutics School of Pharmaceutical Sciences of Araraquara Univ Estadual Paulista - UNESP, São Paulo
Laboratório de Controle de Qualidade Faculdade de Farmácia Universidade Federal de Goiás - UFG, Goiás
Department of Pharmaceutics School of Pharmaceutical Sciences of Araraquara Univ Estadual Paulista - UNESP, São Paulo
