Autor(es):
Singulani, Junya L [UNESP] ; Scorzoni, Liliana [UNESP] ; Da Silva, Patricia B [UNESP] ; Nazaré, Ana C [UNESP] ; Polaquini, Carlos R [UNESP] ; Baveloni, Franciele G [UNESP] ; Chorilli, Marlus [UNESP] ; Regasini, Luis O [UNESP] ; Fusco-Almeida, Ana M [UNESP] ; Mendes-Giannini, Maria J.S. [UNESP]
Data: 2022
Identificador Persistente: http://hdl.handle.net/11449/234170
Origem: Oasisbr
Assunto(s): antifungal activity; nanoparticles; nonconventional animal models; systemic mycosis; toxicity
Descrição
Made available in DSpace on 2022-05-01T13:57:27Z (GMT). No. of bitstreams: 0 Previous issue date: 2022-03-01
Aim: Octyl gallate (OG) loaded into a nanostructured lipid system (NLS) was tested for antifungal activity and in vitro and in vivo toxicity. Methods & Results: The features of NLS-OG were analyzed by dynamic light scattering and showed adequate size (132.1 nm) and homogeneity (polydispersity index = 0.200). OG was active against Paraccoccidioides spp., and NLS-OG did not affect antifungal activity. NLS-OG demonstrated reduced toxicity to lung cells and zebrafish embryos compared with OG, whereas NLS was toxic to hepatic cells. OG and NLS-OG did not show toxicity in a Galleria mellonella model at 20 mg/kg. All toxic concentrations were superior to MIC (antifungal activity). Conclusion: These results indicate good anti-Paracoccidioides activity and low toxicity of NLS-OG.
School of Pharmaceutical Sciences São Paulo State University, Araraquara
Humanities and Exact Sciences Institute of Biosciences São Paulo State University, São José do Rio Preto
Institute of Biological Sciences Federal University of Minas Gerais, Belo Horizonte
Programa de Pós-Graduação em Enfermagem Guarulhos University, Guarulhos
School of Pharmaceutical Sciences São Paulo State University, Araraquara
Humanities and Exact Sciences Institute of Biosciences São Paulo State University, São José do Rio Preto
