Author(s): Santos, Andri L. ; Takeuchi, Regina M. [UNESP] ; Stradiotto, Nelson Ramos [UNESP] ; Esteves, Ana Paula ; Medeiros, Maria Jose
Date: 2014
Persistent ID: http://hdl.handle.net/11449/25820
Origin: Oasisbr
Subject(s): amperometric detection; glassy carbon electrode; chloroacetamides; Teclozan
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Minho University, Portugal
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Sanofi-Synthelabo Brazil Ltda
The electrochemical reduction of amoebicide Teclozan (TEC) was studied on a glassy carbon electrode in acetonitrile. Controlled-potential electrolyses were performed for coulometric and preparative purposes. The electrogenerated products were isolated by liquid-liquid extraction and characterized by (1)H NMR. It was observed that TEC presents two voltammetric peaks, each one associated with the cleavage of two C-Cl bonds. In presence of a proton donor it was observed that the first peak at -1.8 V promotes mainly the reduction of the groups CHCl(2) to CH(2)Cl and the second one at -2.2 V promotes the reduction of the groups CH(2)Cl to CH(3) giving as the sole product the completely dechlorinated TEC derivative with yields between 82 and 97%. In addition, a comparative study between the analytical performance of voltammetric techniques and amperometric detection of TEC in hydrodynamic conditions was performed. The amperometric detection was more sensitive than all evaluated voltammetric techniques, providing a detection limit of 8.9 x 10(-6) mol L(-1).
Universidade Federal de Uberlândia (UFU), Fac Ciencias Integradas Pontal, BR-38302000 Ituiutaba, MG, Brazil
Univ Estadual Paulista, BR-14801970 Araraquara, SP, Brazil
Univ Minho, Ctr Quim, P-4704553 Braga, Portugal
Univ Estadual Paulista, BR-14801970 Araraquara, SP, Brazil
CAPES: 1088068
CAPES: 1087061
FAPESP: 03/05567-7
FAPESP: 03/09334-7
