Autor(es): Carvalho, Carina Martins ; Castro, Vânia I. B. ; Lima, Sílvia M. M. A. Pereira ; Costa, Susana P. G.
Data: 2014
Identificador Persistente: http://hdl.handle.net/1822/32324
Origem: RepositóriUM - Universidade do Minho
Projeto/bolsa: info:eu-repo/grantAgreement/FCT/5876-PPCDTI/118389/PT ; info:eu-repo/grantAgreement/FCT/COMPETE/118389/PT;
Assunto(s): Peptide; Fluorescence spectroscopy; Membrane permeation; Ciências Naturais::Ciências Químicas
Comunicação em painel P3
The membrane permeabilization ability of a model peptaibol and several mimetics incorporating unnatural α,α- dialkylglycines were studied by fluorescence spectroscopy. The model membranes (egg phosphatidylcholine/cholesterol, 70:30) contained a fluorescent probe encapsulated. By addition of peptides at different peptide to lipid ratios, it was possible to follow the release of the encapsulated probe, monitoring the increase in fluorescence intensity over time using fluorescence spectroscopy.
Fundação para a Ciência e a Tecnologia (FCT), através de projecto PTDC/QUI-BIQ/118389/2010 (FCOMP-01-0124-FEDER-020906).
