Optimizations studies on the microwave assisted synthesis of antimicrobial Peptaibols

• Author(s): Castro, Vânia I. B. ; Carvalho, Carina Martins ; Fernandes, Rui D. V. ; Aguiam, Nádia ; Costa, Susana P. G. ; Pereira-Lima, Sílvia M. M. A.
• Date: 2013
• Persistent ID: http://hdl.handle.net/1822/37372
• Origin: RepositóriUM - Universidade do Minho
• Project/scholarship: info:eu-repo/grantAgreement/FCT/5876-PPCDTI/118389/PT ; info:eu-repo/grantAgreement/FCT/COMPETE/118389/PT
• Subject(s): Peptaibols; Microwave assisted synthesis
• Document Type: Conference object
• Language: English
• Contributor(s): Universidade do Minho

Description

We present a systematic study on the best conditions to achieve the microwave-assisted solid phase peptide synthesis of a selected peptaibol, namely the pentapeptide Peptaibolin (Ac-Leu-Aib-Leu-Aib-Phol), by using several resins and different coupling and cleavage conditions aiming at a future synthesis of mimetics of larger members of the peptaibol family bearing bulkier unnatural α,α-dialkylglycines.