Author(s): Sá, M. ; Azóia, Nuno G. ; Melle-Franco, Manuel ; Ribeiro, Artur ; Cavaco-Paulo, Artur
Date: 2017
Persistent ID: http://hdl.handle.net/1822/46390
Origin: RepositóriUM - Universidade do Minho
Project/scholarship: info:eu-repo/grantAgreement/FCT/5876/147337/PT; info:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBPD%2F98388%2F2013/PT;
Subject(s): Delivery; Dispersion; Fullerene C60; Transdermal; Cosmetics; Science & Technology
Dispersions in transcutol/isopropyl myristate make C60 fullerene molecules suitable for transdermal delivery. We found that C60 can successfully permeate the skin using pig skin in Franz diffusion cells. Molecular dynamics simulations and transmission electron microscopy confirmed these observations. Basic cosmetic formulations with transcutol/ isopropyl myristate without harsh organic solvents show a high potential for delivery of C60 for biopharmaceutical and cosmetics applications.
This study was supported by the Portuguese Foundation for Science and Technology (FCT) under the scope of the strategic funding of UID/BIO/04469/2013 unit and COMPETE 2020 (POCI01-0145-FEDER-006684).). Artur Ribeiro thanks FCT for the SFRH\BPD\98388\2013 grant.
info:eu-repo/semantics/publishedVersion
