Author(s):
Ferreira, Débora ; Martins, Ivone M.
Date: 2017
Persistent ID: https://hdl.handle.net/1822/56508
Origin: RepositóriUM - Universidade do Minho
Project/scholarship:
info:eu-repo/grantAgreement/FCT/5876/147337/PT;
info:eu-repo/grantAgreement/FCT/5876-PPCDTI/126270/PT
;
info:eu-repo/grantAgreement/FCT/COMPETE/126270/PT;
info:eu-repo/grantAgreement/FCT/5876-PPCDTI/121028/PT
;
info:eu-repo/grantAgreement/FCT/COMPETE/121028/PT;
Subject(s): Virus-like particles; Viral nanoparticles; Bacteriophages; Genetic engineering; Chemical modifications; Biomedical applications.; Science & Technology
Description
This chapter intends to provide an overview of the use of viruses for medical applications. The first part describes the basic characteristics of viral particles regarding their chemical composition and size, as well as their structure and assembly/disassembly abilities. Next, a discussion about the newest and most important strategies for virus particles modification including genetic, chemical, and self-assembly/encapsulation engineering towards the development of new virus particles for biomedical applications, including targeted delivery and therapy, molecular imaging for disease detection, vaccine development, and bacterial infection control.
The authors acknowledge financial support from the Portuguese Foundation for Science and Technology (FCT) under the scope of the strategic funding of UID/BIO/04469/2013 unit and COMPETE 2020 (POCI-01-0145-FEDER-006684), and also under the scope of the Projects RECI/BBB-EBI/0179/2012 (FCOMP-01-0124-FEDER-027462) and Lipid NP’Phage (PTDC/ SAU-BMA/121028/2010).
info:eu-repo/semantics/publishedVersion
