The presence of chitosan at the surface influences the interaction of biomolecules and cells with chitosan-poly (bultylene succinate) blend

• Author(s): Coutinho, D. F. ; Pashkuleva, I. H. ; Alves, C. M. ; Marques, A. P. ; Neves, M. ; Reis, R. L.
• Date: 2008
• Persistent ID: https://hdl.handle.net/1822/59178
• Origin: RepositóriUM - Universidade do Minho
• Subject(s): Science & Technology
• Document Type: Conference object
• Language: English
• Contributor(s): Universidade do Minho

Description

[Excerpt] Chitosan blends with synthetic biodegradable biomaterials have been proposed for various biomedical applications. However, there are still missing details about the main surface characteristics that may benefit from the blending of these two types of materials. Hence, this work aims at characterising the surface properties of those materials and at illustrating how these properties outline the interaction with proteins involved in cell adhesion and consequently with osteoblast-like cells. Etching by polishing or by plasma was performed to compare the composition of the surface with that of the bulk. The characterization of the unmodified and modified surfaces was carried out by optical microscopy, scanning electron microscopy, Fourier Transform Infrared spectroscopy, X-Ray photoelectron spectroscopy, contact angle measurements and surface energy calculations. [...]

info:eu-repo/semantics/publishedVersion