Author(s):
Souza, Jefferson M. ; Henriques, Mariana ; Teixeira, Maria Pilar Araújo ; Fernandes, Margarida Maria Macedo ; Fangueiro, Raúl ; Zille, Andrea
Date: 2019
Persistent ID: http://hdl.handle.net/1822/60293
Origin: RepositóriUM - Universidade do Minho
Project/scholarship:
info:eu-repo/grantAgreement/FCT/5876/147331/PT;
info:eu-repo/grantAgreement/FCT/5876-PPCDTI/119069/PT
;
info:eu-repo/grantAgreement/FCT/COMPETE/119069/PT;
info:eu-repo/grantAgreement/FCT/5876-PPCDTI/126270/PT
;
info:eu-repo/grantAgreement/FCT/COMPETE/126270/PT;
info:eu-repo/grantAgreement/FCT/3599-PPCDT/132966/PT;
info:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBPD%2F86732%2F2012/PT;
Subject(s): Chitosan; Cellulose; Comfor; Antimicrobial; Wound dressing; Textile; Comfort; Science & Technology
Description
The aim of this study was to evaluate the thermo-physiological comfort properties of surgical cotton gauze coated with chitosan (CH) and its effectiveness for the prevention of bacterial colonization. Gauze was coated with CH at mass fractions of 0.50, 0.25, 0.125, 0.10, 0.063 wt% and the friction, flexibility, thermal, moisture management and mechanical properties were evaluated. The best performing gauze in terms of comfort (0.125 wt%) was further evaluated for its ability to inhibit the growth of microorganisms such as bacteria and yeast. Results indicate that the functionalized medical gauze could induce low friction on the wound bed allowing a good degree of moisture and high absorption capacity of wound exudates. Moreover, it shows antimicrobial properties against medical-relevant pathogens. This biofunctional medical gauze demonstrates to deliver an efficient antimicrobial coating and promote the best conditions for maintenance of the wound microenvironment.
Z acknowledges funding from FCT - Fundação para a Ciência e a Tecnologia within the scope of the project POCI- 01-0145-FEDER-007136 and UID/CTM/00264. A. Zille also acknowledges financial support of the FCT through an Investigator FCT Research contract (IF/00071/2015). JS acknowledge CAPES Foundation, Ministry of Education of Brazil, Proc. no 8976/13-9 and the Department of Textile Engineering of the University of Minho, Portugal. The work regarding the biological analysis was supported by the Programa Operacional, Fatores de competitividade - COMPETE and by national funds through FCT on the scope of the projects PTDC/SAU-MIC/119069/2010, RECI/EBB-EBI/ 0179/2012 and PEst-OE/EQB/LA0023/2013. PT acknowledges SFRH/BPD/86732/2012 grant. The authors thank the Project BioHealth - Biotechnology and Bioengineering approaches to improve health quality, Ref. NORTE-07-0124-FEDER- 000027, co-funded by the Programa Operacional Regional do Norte (ON.2 - O Novo Norte), QREN, FEDER.
info:eu-repo/semantics/publishedVersion
