Author(s):
Lopes, Maria Beatriz Afonso Sequeira ; Silva, Maria Daniela Ferreira ; Azeredo, Joana ; Melo, Luís Daniel Rodrigues
Date: 2025
Persistent ID: https://hdl.handle.net/1822/93725
Origin: RepositóriUM - Universidade do Minho
Project/scholarship:
info:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F04469%2F2020/PT;
info:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FBIA-MIC%2F2312%2F2020/PT;
info:eu-repo/grantAgreement/FCT/POR_NORTE/2021.05940.BD/PT;
Subject(s): Bacteriophages; Coagulase-negative staphylococci; Genomic diversity; in vitro studies
Description
Coagulase-negative staphylococci (CoNS) are commensal bacteria of the human skin and mucosal membranes. The incidence of nosocomial infections caused by these species is on the rise, leading to a potential increase in antibiotic tolerance and resistance. Phages are emerging as a promising alternative to combat CoNS infections. Scientists are isolating phages infecting CoNS with a particular interest in S. epidermidis. This review compiles and analyses CoNS phages for several parameters including source, geographical location, host species, morphological diversity, and genomic diversity. Additionally, recent studies have highlighted the potential of these phages based on host range, in vitro evaluation of performance and stability, and interaction with biofilms. This comprehensive analysis enables a better understanding of the steps involved in using these phages for therapeutic purposes.
This work was supported by the Portuguese Foundation for Science and Technology (FCT) under the scope of the strategic funding of UIDB/04469/2020 unit and project PTDC/BIA-MIC/2312/2020 (http://doi. org/10.54499/PTDC/BIA-MIC/2312/2020) and by LABBELS–Associate Laboratory in Biotechnology, Bioengineering and Micro electromechanical Systems, LA/P/0029/2020. L.D.R.M. acknowledges funding from the FCT through the Scientific Employment Stimulus Program (https://doi.org/10.54499/2021.00221.CEECIND/CP1664/CT0002). M.S.L also acknowledge FCT for the fellowship (2021.05940.BD).
info:eu-repo/semantics/publishedVersion
